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Phosphorus-31 in vivo human cardiac magnetic resonance spectroscopy development of MR spectroscopy techniques by Hee-Won Kim

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Published .
Written in English

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Edition Notes

Statementby Hee-Won Kim
The Physical Object
Paginationxvi, 142 leaves :
Number of Pages142
ID Numbers
Open LibraryOL25915579M

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Phosphorus magnetic resonance spectroscopy (31 P-MRS) makes a unique and valuable contribution to our understanding of metabolism 1 – 4. Applied in the human heart 5, 31 P-MRS reveals the biochemistry of ATP, ADP, and phosphocreatine (PCr), which are critical to the supply of energy for contractile work in the by: We have studied the metabolism of compounds containing 31 P in normal breast using magnetic resonance spectroscopy (MRS). Spectra were acquired from non-lactating pre-menopausal breast (n = 14 women), lactating breast (n = 8) and post-menopausal breast (n = 8). The standard acquisition protocol used a cm surface coil with the volunteer prone to minimize chest wall signal by: Abstract. To evaluate the changes in hepatocellular phospholipid metabolism during hepatitis virus infection, 26 patients with acute viral hepatitis A were studied by means of phosphorus nuclear magnetic resonance (31 P-NMR) spectroscopy of liver showed six signal components in all patients as well as in the normal by: A priori, the human heart is one of the most difficult organs in the body from which to acquire a phosphorus (31 P) nuclear magnetic resonance (NMR) spectrum. Its asymmetric location within the trunk necessitates the use of a full-sized-body NMR system, and the depth of the anterior wall relative to the chest can vary from 2 to 10 cm in patients, placing severe demands on signal-to-noise ratio when .

Abstract Phosphorus nuclear magnetic resonance (NMR) spectroscopy has become popular for the characterization of P species in environmental samples. However, these are commonly made alkaline (pH > 13) to facilitate sample comparison and ease peak identification, but this may cause hydrolysis of some compounds. Background 31 P metabolite measurements in the human heart by magnetic resonance spectroscopy (MRS) have been reported previously. By use of a method in which metabolite content was quantified with reference to a standard located outside the chest, it has become possible to measure the content of phosphocreatine (PCr) and ATP in vivo in the human heart.   Cardiovascular magnetic resonance (CMR) imaging uses the 1 H nucleus in water (H 2 O) and fat (CH 2 and CH 3 groups) molecules as its only signal source, and therefore offers little insight into the biochemical state of cardiac tissue. In contrast, MR spectroscopy (MRS) of the heart allows the study of many other nuclei. 39 rows  In vivo magnetic resonance spectroscopy (MRS) is a specialized technique associated .

Phosphorus nuclear magnetic resonance spectroscopy can determine the status of high energy phosphates in vivo. However, its application to human cardiac studies requires precise spatial localization without significant contamination from other tissues. Using image-selected in-vivo spectroscopy (ISIS), a technique that allows three-dimensional localization of the volume of interest, . Phosphorus (31P) magnetic resonance spectroscopy (MRS) performed in clinical cardiovascular magnetic resonance imaging (CMR) scanners, is uniquely able to noninvasively measure the ratios and concentrations of endogenous cardiac high-energy phosphate metabolites, as well as CK flux in human hearts [8–11, 16–22]. Cerebral phosphorus‐31 magnetic resonance spectroscopy was undertaken in 33 patients with biopsyproven cirrhosis: 6 had no evidence of neuropsychiatric impairment on standard clinical, psychometric and electrophysiological testing; 8 had evidence of subclinical hepatic encephalopathy; and 19 were classified as having overt hepatic encephalopathy. Andre Syrota, Philippe Jehenson, Complementarity of magnetic resonance spectroscopy, positron emission tomography and single photon emission tomography for the in vivo investigation of human cardiac metabolism and neurotransmission, European Journal of Nuclear Medicine, /BF, 18, 11, (), ().